Since both Full Spectrum Hemp Oil and corticosteroids are potent inhibitors of the CYP450 enzyme system, concomitant use may increase the risk of systemic side effects from corticosteroid use due to decreased glucocorticoid clearance. Corticosteroids like prednisolone and hydrocortisone should never be taken with Full Spectrum Hemp Oil.
CBD and prednisone can be taken together safely, but the dose of both substances may need to be modified. Always ask your doctor about taking CBD if you have a prescription for prednisone.